Short course


Understanding Mechanisms of ICP-MS/MS for Resolving Polyatomic, Isobaric, and Other Spectral Interferences

This short course will cover the fundamentals of ICP-MS/MS (tandem mass spectrometry) and explain the benefits of MS/MS for resolving problematic spectral interferences. Examples of methods that address specific interferences will be used to illustrate the potential for ICP-MS/MS in supporting new applications and improving accuracy and reliability of data in established methods.

In the first part of the course, we will introduce the concepts of ICP MS/MS. We will explain the approaches that can be used to resolve spectral interferences with reaction chemistry, using either on-mass or mass-shift measurement. Potential pitfalls of each approach will be presented, along with the methodology used to overcome them. The key hardware and operating parameters that contribute to successful analysis will be described.

In the second part we will use practical examples to explain the different measurement modes available with ICP-MS/MS, illustrating the performance using applications that have proved difficult for conventional quadrupole ICP-MS and, in some cases, high-resolution sector field ICP-MS. Various reaction gases and reaction chemistries will be discussed, and we will introduce the potential for ICP-MS/MS to address new applications not previously possible using ICP-MS.

  • 1. The technology behind ICP-MS/MS, and how it compares to conventional quadrupole ICP-MS
  • 2. Insight into the unique measurement modes available to support method development
  • 3. Examples where MS/MS methods offer practical benefits for challenging applications


Glenn Woods

ICP-MS Applications Specialist
Agilent Technologies LDA UK Ltd.

I have been with HP/Agilent using ICP-MS for over 18 years and was a user of ICP-MS, OES and AA before this. I studied Applied Chemistry at Sheffield Hallam University for four years including an industrial placement which got me interested in the world of ICP-OES. I then worked as a post graduate at the University of Sheffield on ICP-MS environmental analysis (primarily seawater) where I was first introduced to the Hewlett-Packard HP4500 ICP-MS.

I then Joined HP in June 98 as ICP-MS chemist and since then have seen the formation of Agilent and been involved with the introduction of the 7500a/i/s then the 7500c (first cell-based instrument) followed by the 2nd generation cell 7500ce/cx then the 7700 ICP-MS and was very fortunate to be chosen to be one of the first 8800 ICP-QQQ field testers.

Now with the 7800 and 7900 ICP-MS and newly-introduced 8900 ICP-QQQ the world of ICP-MS is as exciting and novel as ever.

Naoki Sugiyama

ICP-MS Product Marketing
Agilent Technologies International Japan, Ltd.

graduated Tokyo Institute of Technology
oined Yokogawa Electric Corporation R&D
moved Agilent Japan and joined Agilent 7500 R&D team
moved product marketing division to be an Agilent 7700 product manager ( - 2010 )
2010 - 2013
Agilent 8800 product manager
2014 - 2016
Agilent 8900 product manager




    University of Natural Resources and Life Sciences


    Department of Chemistry


    Division of Analytical Chemistry



    Konrad Lorenz Straße 24


    3430 Tulln a.d. Donau



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